News Express: UM scholar gives talk on research on immune checkpoints in cancer
新聞快訊：澳大學人分享腫瘤免疫檢查點研究
唐正海
Tang Zhenghai
澳大學人分享腫瘤免疫檢查點研究
澳門大學今（25）日舉行“澳大學人研究講壇”第29講，由澳大健康科學學院助理教授唐正海圍繞“腫瘤免疫檢查點的開發瓶頸與機遇”發表演說。講座現場反應熱烈，一眾師生以線上線下形式參與。
講座中，唐正海介紹了免疫檢查點抑制劑在腫瘤治療中的發展，儘管抑制劑於過去十年成效顯著，但仍有七成以上患者未能產生療效。對此，他認為主因在於免疫檢查點機制的複雜性未被充分認識。他深入解析了該機制，揭示腫瘤免疫檢查點除了傳統的反式結合外，還可經由順式結合抑制免疫細胞的抗腫瘤活性。據此，他研製出全新的腫瘤治療抗體，其顯著的抗腫瘤效果，印證了開發有效的腫瘤免疫檢查點抑制劑必須同時考量反式與順式作用機制。
唐正海致力研究腫瘤治療的新型免疫檢查點並開發治療性抗體，相關成果已發表於《自然-免疫學》、《科學免疫學》、《細胞報告》等知名期刊。其科研曾獲國家自然科學基金青年科學基金項目（B類）（原優秀青年科學基金項目）及澳門科學技術發展基金等資助。
“澳大學人研究講壇”由澳大研究服務及知識轉移辦公室舉辦，邀請傑出的澳大學人以通俗易懂的方式介紹其前沿研究成果，讓大眾了解研究創新的社會意義，以及與日常生活密切關聯的應用性。
欲瀏覽官網版可登入以下連結:
https://www.um.edu.mo/zh-hant/news-and-press-releases/press-release/detail/62712/
UM scholar gives talk on research on immune checkpoints in cancer
The University of Macau (UM) held the 29th UM Scholar Research Forum today (25 November), where Tang Zhenghai, assistant professor in the Faculty of Health Sciences at UM, delivered a talk titled ‘Immune Checkpoints in Cancer: Challenges and Opportunities’. The talk was well attended, with many students and faculty participating in person and online.
During the talk, Prof Tang outlined the development of immune checkpoint inhibitors in cancer treatment. He noted that although there has been remarkable progress in the use of these inhibitors over the past decade, more than 70% of patients still do not benefit from them, largely because the understanding of immune checkpoint mechanisms remains limited. He explained that tumour immune checkpoints inhibit immune cells through both trans and cis interactions, and based on this insight, he developed a new therapeutic antibody with significant anti‑tumour effects.
To read the news on UM’s official website, please visit the following link:
https://www.um.edu.mo/news-and-press-releases/press-release/detail/62712/