News Express: Xplorer Symposia held at UM
bellleong2025-06-03T19:16:37+08:00
頂尖學者於澳大分享細胞器研究突破
Leading scholars share breakthroughs in organelle research at UM
50²科學研討會於澳大舉行
由新基石科學基金會主辦、澳門大學健康科學學院協辦的“50²科學研討會:細胞器的結構、功能與疾病”在澳大舉行。研討會邀請諾貝爾獎得主、加州大學柏克萊分校教授Randy Wayne Schekman等31位來自海內外知名學府的頂尖學者共同探討細胞器研究領域的最新科研成果。
開幕儀式上,澳門大學副校長葛偉,研討會主席、清華大學副教授葛亮,新基石科學基金會代表邱春紅分別致辭歡迎與會嘉賓。研討會設有五大主題分場及31場專題報告,涵蓋細胞器結構與動態、膜運輸機制、細胞器與代謝、細胞器與病原體互作、細胞器與訊號傳導等領域。來自加州大學柏克萊分校、康奈爾大學、威斯康辛大學麥迪遜分校、因斯布魯克醫科大學、法蘭西斯•克里克研究所、清華大學、北京大學、浙江大學、中國科學院生物物理研究所、上海交通大學、復旦大學、香港科技大學、澳門大學等高等學府的專家學者發表多場高水準學術報告。
研討會上,Schekman教授系統闡述了細胞外囊泡的起源與功能,並重點介紹了其於細胞內穩態調控中的作用,尤其是外泌體作為細胞間物質傳輸關鍵媒介的最新研究進展。清華大學教授俞立發表了關於“自噬層狀體(Autolamellosome)”形成機制及其在病理狀態下的功能研究,當中指出自噬層狀體在維持內質網穩定性及應對與老化相關的疾病中扮演了關鍵角色。因斯布魯克醫科大學教授Hesso Farhan則介紹了機械力如何影響內質網的結構與功能,進而調節細胞內蛋白質的穩態,並發表了內質網蛋白IRE1在細胞感知機械力過程中的最新研究進展。中國科學院生物物理研究所研究員胡俊傑報告了細胞跨膜受體LEPROTs蛋白在高爾基體中的運輸路徑,並探討了其在運輸過程中所經歷的修飾調控機制及其生物學功能。浙江大學助理教授馬亮則分享了關於特定微小RNA(miRNA)如何先進入線粒體,隨後再被轉運至外泌體的研究成果,揭示了細胞間溝通的新機制。
除主會場報告外,會議亦設有專題海報展示環節,展出海內外高校與科研機構的31項研究成果,由參展學生與研究人員向與會者介紹。經專家評審,最佳海報獎由香港大學黃亦馨、澳門大學謝黎明及清華大學鄭健飛三位青年學者獲得。
是次研討會由澳門大學健康科學學院副院長沈漢明教授、南開大學研究員邊鑫及南方科技大學副教授趙燕共同擔任聯合主席。研討會內容豐富,促進了跨學科交流與合作,獲與會者一致好評。
欲瀏覽官網版可登入以下連結:
https://www.um.edu.mo/zh-hant/news-and-press-releases/press-release/detail/61257/
Xplorer Symposia held at UM
The ‘Xplorer Symposia—Organelles: Structure, Function, and Disease’, organised by the New Cornerstone Science Foundation and co-organised by the Faculty of Health Sciences (FHS) of the University of Macau (UM), was held at UM. The event brought together 31 leading scholars from prestigious institutions around the world to explore the latest findings in organelle research. Among them was Randy Wayne Schekman, Nobel laureate and professor at the University of California, Berkeley.
During the opening ceremony, Wei GE, vice rector of UM; Ge Liang, chair of the symposium and associate professor at Tsinghua University; and Qiu Chunhong, representative of the New Cornerstone Science Foundation, delivered welcome remarks. The three-day symposium featured five sessions, each covering a different topic: organelle structure and dynamics, membrane trafficking, organelle and metabolism, organelle and pathogen interaction, and organelle and signalling. A total of 31 presentations were given throughout these sessions by experts and scholars from renowned institutions such as the University of California, Berkeley, Cornell University, the University of Wisconsin–Madison, the Medical University of Innsbruck, Francis Crick Institute, Tsinghua University, Peking University, Zhejiang University, the Institute of Biophysics of the Chinese Academy of Sciences, Shanghai Jiao Tong University, Fudan University, the Hong Kong University of Science and Technology, and UM.
At the symposium, Prof Schekman explained the origin and functions of extracellular vesicles, with particular focus on their role in regulating intracellular homeostasis and the latest advances in exosomes as key mediators of intercellular communication. Yu Li, professor at Tsinghua University, presented his research on the formation mechanism and pathological functions of autolamellosome, highlighting its critical role in maintaining endoplasmic reticulum (ER) homeostasis and combating aging-related diseases. Hesso Farhan, professor at the Medical University of Innsbruck, explained how mechanical forces influence the structure and function of ER and regulate intracellular protein homeostasis. He also presented his latest research on the role of ER protein IRE1 in cellular mechanosensing. Hu Junjie, researcher at the Institute of Biophysics of the Chinese Academy of Sciences, reported on the intracellular trafficking of the transmembrane receptor protein LEPROT within the Golgi apparatus. He also discussed the regulatory mechanisms that occur during this process, and the biological functions of the protein. Ma Liang, assistant professor at Zhejiang University, presented his research on how specific microRNAs (miRNAs) are first enriched in mitochondria before being sorted into exosomes, revealing a novel mechanism of intercellular communication.
The symposium also featured a poster session, which showcased 31 research projects from higher education institutions and research institutes around the world. Participating students and researchers presented their findings to attendees. Following evaluation by experts, the Best Poster Awards were presented to three young scholars: Huang Yixin from the University of Hong Kong, Xie Liming from UM, and Zheng Jianfei from Tsinghua University.
The symposium was co-chaired by Shen Hanming, associate dean of FHS; Bian Xin, researcher at Nankai University; and Zhao Yan, associate professor at Southern University of Science and Technology. With its rich programme, the symposium facilitated interdisciplinary exchange and collaboration and was well received by attendees.
To read the news on UM’s official website, please visit the following link:
https://www.um.edu.mo/news-and-press-releases/press-release/detail/61257/